ORAL CONTROLLED RELEASE MATRIX FORMULATION DESIGN AND THEIRRATE CONTROLLING FACTORS

Abstract

The trend of formulation development of controlled release (CR) matrix drug delivery system has been
increased to many folds during the last few years. Such CR dosage forms are now considered to be more
effective than conventional immediate release dosage formulations due to avoidance of frequent dose
administration with precise drug release over an extended time period. A properly formulated matrix based
system also offers targeted delivery to a selected organ/tissue where the drug release is controlled at a
specific rate. Development of matrix-based tablets with persistent drug release has always been a challenge
to the pharmaceutical manufacturers owed to various biological, physicochemical and release limiting
factors. In this review, different types of matrix-based systems are discussed in detail. Parameters that
greatly influence the release of active pharmaceutical ingredient (API) from the matrix design and would
eventually affect the overall performance of such products are also been highlighted